Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neonatal cholestasis.

F M Karrer1, D D Bensard

  • 1Division of Pediatric Surgery, University of Colorado Health Sciences Center, Denver, USA.

Seminars in Pediatric Surgery
|December 12, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

TNF receptor I mediates chemokine production and neutrophil accumulation in the lung following systemic lipopolysaccharide.

The Journal of surgical research·2001
Same author

Extraperitoneal placement of renal allografts in children weighing less than 15 kg.

The Journal of urology·2001
Same author

Survival after first esophageal variceal hemorrhage in patients with biliary atresia.

The Journal of pediatrics·2001
Same author

Life-threatening dog attacks: a devastating combination of penetrating and blunt injuries.

Journal of pediatric surgery·2001
Same author

Suppression of tumor necrosis factor alpha production by cAMP in human monocytes: dissociation with mRNA level and independent of interleukin-10.

The Journal of surgical research·2001
Same author

L-arginine attenuates lipopolysaccharide-induced lung chemokine production.

American journal of physiology. Lung cellular and molecular physiology·2001
Same journal

The EXTra-uterine Environment for Neonatal Development (EXTEND) - future treatment for prematurity and potentially other congenital disease.

Seminars in pediatric surgery·2026
Same journal

Appendicitis as a model for pediatric surgical quality improvement and standardization.

Seminars in pediatric surgery·2026
Same journal

From FOB to PICU: military trauma systems that changed pediatrics.

Seminars in pediatric surgery·2026
Same journal

Long-term follow-up after surgery for congenital anomalies: A time to complication analysis.

Seminars in pediatric surgery·2026
Same journal

Radio-surgical decision-making in hepatoblastoma in the post-PHITT era: SIOPEL consensus recommendations.

Seminars in pediatric surgery·2026
Same journal

Seminars in pediatric sugery pediatric metabolic and bariatric surgery.

Seminars in pediatric surgery·2026
See all related articles

Cholestasis is reduced bile flow, causing bilirubin, bile acid, and cholesterol buildup. This leads to jaundice, pruritus, and hypercholesterolemia in infants, with causes ranging from physiologic jaundice to biliary atresia.

Area of Science:

  • Hepatology and Gastroenterology
  • Pediatric Medicine

Background:

  • Cholestasis is characterized by a decrease in bile flow.
  • Clinical signs result from the accumulation of substances normally excreted in bile, including bilirubin, bile acids, and cholesterol.
  • Manifestations include jaundice, dark urine, pruritus, hypercholesterolemia, and xanthomas.

Purpose of the Study:

  • To define cholestasis and its clinical manifestations.
  • To outline the spectrum of causes of cholestasis in early infancy.

Main Methods:

  • This abstract is a definition and overview of cholestasis.
  • No specific methods were employed for this definitional abstract.

Main Results:

  • Accumulation of bilirubin causes jaundice and dark urine.

Related Experiment Videos

  • Accumulation of bile acids leads to pruritus.
  • Accumulation of cholesterol results in hypercholesterolemia and xanthomas.

    • Conclusions:

    • Cholestasis presents with diverse clinical signs depending on the accumulated substance.
    • Infantile cholestasis has a wide range of etiologies, from benign to severe biliary obstruction like biliary atresia.