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Related Concept Videos

Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

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Prospective predictors of exacerbation status in severe asthma over a 3-year follow-up.

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Related Experiment Video

Updated: Jul 13, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Pathophysiology of severe asthma.

W W Busse1, S Banks-Schlegel, S E Wenzel

  • 1Department of Medicine, University of Wisconsin, Madison, USA.

The Journal of Allergy and Clinical Immunology
|December 12, 2000
PubMed
Summary

Severe asthma affects 5-10% of adults and is difficult to treat. Research is needed to understand its characteristics and develop new therapies for this challenging condition.

Area of Science:

  • Pulmonology
  • Clinical Medicine
  • Pathogenesis Research

Background:

  • Asthma impacts 8% of adults, with most having mild-to-moderate forms.
  • Severe asthma (5-10% of cases) is unresponsive to standard treatments like corticosteroids.
  • Severe asthma significantly impairs quality of life and increases healthcare costs.

Purpose of the Study:

  • To define the characteristics of severe asthma.
  • To explore potential mechanisms underlying severe asthma.
  • To identify research needs for severe asthma management.

Main Methods:

  • Workshop sponsored by the National Heart, Lung, and Blood Institute.
  • Discussion of asthma phenotypes, including symptoms, treatment intensity, and lung function.

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Murine Model of Allergen Induced Asthma
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Murine Model of Allergen Induced Asthma

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Mouse Model of Oleic Acid-Induced Acute Respiratory Distress Syndrome

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Last Updated: Jul 13, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Mouse Model of Oleic Acid-Induced Acute Respiratory Distress Syndrome
04:45

Mouse Model of Oleic Acid-Induced Acute Respiratory Distress Syndrome

Published on: June 2, 2022

  • Review of potential pathogenic mechanisms and treatment limitations.

    • Main Results:

    • Defining severe asthma requires considering symptoms, therapy intensity, and lung function impairment.
    • Allergic diseases may play a lesser role in severe asthma compared to milder forms.
    • Recalcitrant response to corticosteroids is a major challenge in severe asthma control.

    Conclusions:

    • Further research is essential to understand the novel mechanisms of severe asthma.
    • Identifying new therapeutic targets is crucial for managing this difficult-to-treat condition.
    • Collaboration and focused research are needed to improve outcomes for severe asthma patients.