Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endogenous antipyretics.

J B Tatro1

  • 1Division of Endocrinology, Diabetes, Metabolism and Molecular Medicine, Department of Medicine, Tupper Research Institute, Tufts University School of Medicine and New England Medical Center, Boston, MA 02111, USA. jtatro@lifespan.org

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|December 13, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hypothalamic melanocortin signaling in cachexia.

Endocrinology·2001
Same author

alpha-Melanocyte stimulating hormone prevents fasting-induced suppression of corticotropin-releasing hormone gene expression in the rat hypothalamic paraventricular nucleus.

Neuroscience letters·2000
Same author

Hypophysiotropic thyrotropin-releasing hormone-synthesizing neurons in the human hypothalamus are innervated by neuropeptide Y, agouti-related protein, and alpha-melanocyte-stimulating hormone.

The Journal of clinical endocrinology and metabolism·2000
Same author

alpha-Melanocyte-stimulating hormone is contained in nerve terminals innervating thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus and prevents fasting-induced suppression of prothyrotropin-releasing hormone gene expression.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2000
Same author

Role of central melanocortins in endotoxin-induced anorexia.

The American journal of physiology·1999
Same author

Expression of melanocortin receptors and pro-opiomelanocortin in the rat spinal cord in relation to neurotrophic effects of melanocortins.

Brain research. Molecular brain research·1999

Fever is a host defense strategy, but the body has natural systems to control it. Understanding these antipyretic systems can lead to new treatments for fever and inflammation.

Area of Science:

  • Immunology
  • Neuroscience
  • Physiology

Background:

  • Fever is a key host defense mechanism against microbial infections.
  • The febrile response is regulated by endogenous antipyretic systems that limit its intensity and duration.
  • These systems involve neuroactive substances like glucocorticoids, melanocortins, and IL-10, which also possess anti-inflammatory properties.

Purpose of the Study:

  • To investigate the physiological role of endogenous antipyretic systems in regulating fever.
  • To explore the neural and biochemical mechanisms underlying fever suppression.
  • To identify potential therapeutic targets for novel antipyretic and anti-inflammatory strategies.

Main Methods:

  • The abstract does not specify methods, but implies studies on host defense mechanisms and fever regulation.

Related Experiment Videos

  • Research likely involves investigating the effects of blocking endogenous antipyretic systems.
  • Analysis of neuroactive substances and their receptor interactions within the brain.

    • Main Results:

    • Endogenous antipyretic systems, including glucocorticoids, vasopressin, and melanocortins, act on brain receptors to reduce fever.
    • Pharmacological blockade of these systems exacerbates fever, even at low intensities.
    • These systems play a fundamental role in determining the normal course of fever.

    Conclusions:

    • Endogenous antipyretic systems are crucial for controlling fever and preventing potential harm from unchecked high temperatures.
    • Elucidating these mechanisms advances our understanding of host defense strategies.
    • This knowledge can inform the development of new therapeutic interventions for inflammatory diseases and fever management.