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Published on: May 24, 2018
Elevated bound leptin correlates with energy expenditure in cirrhotics
J Ockenga1, S C Bischoff, H L Tillmann
1Department of Gastroenterology and Hepatology, Hannover Medical School, Hannover, Germany. Ockenga.Johann@mh-hannover.de
Gastroenterology
|December 13, 2000
Summary
In liver cirrhosis patients, elevated bound leptin, not free leptin, correlates with increased energy expenditure. Bound leptin may indicate inadequate energy expenditure in these patients.
Area of Science:
- Endocrinology
- Metabolism
- Hepatology
Background:
- Leptin levels are elevated in liver cirrhosis patients.
- This elevation may contribute to malnutrition and poor prognosis.
- The relationship between leptin components and energy metabolism in cirrhosis is not fully understood.
Purpose of the Study:
- To characterize free and bound leptin levels in posthepatic liver cirrhosis.
- To examine the relationship between leptin components, body composition, and resting energy expenditure (REE).
Main Methods:
- Radioimmunoassays were used to measure free and bound leptin in 27 cirrhotics and 27 controls.
- Body composition and REE were determined in the cirrhotic group.
Main Results:
- Free leptin levels did not differ between cirrhotics and controls.
- Free leptin correlated with body mass index and fat mass in both groups.
- Bound leptin was significantly higher in cirrhotics and correlated with energy expenditure metrics.
Conclusions:
- Free leptin reflects fat mass in both healthy individuals and cirrhotic patients.
- Increased total serum leptin in cirrhosis is due to elevated bound leptin.
- Bound leptin may serve as a marker for inadequate energy expenditure in liver cirrhosis.
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