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Mental changes associated with hyperparathyroidism.

J W Gatewood, C H Organ, B T Mead

    The American Journal of Psychiatry
    |February 11, 1975
    PubMed
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    Primary hyperparathyroidism can cause unexplained neurological and psychiatric symptoms. Further research into magnesium

    Area of Science:

    • Neurology
    • Psychiatry
    • Endocrinology

    Background:

    • Hyperparathyroidism is often associated with bone and kidney issues.
    • Neurological and psychiatric symptoms are not typically linked to hyperparathyroidism.

    Purpose of the Study:

    • To highlight primary hyperparathyroidism as a potential cause of unexplained neurological and psychiatric symptoms.
    • To present case studies of patients with primary hyperparathyroidism and psychiatric manifestations.

    Main Methods:

    • Case report analysis of five patients with confirmed primary hyperparathyroidism.
    • Review of relevant medical literature on hyperparathyroidism and central nervous system effects.
    • Discussion of the impact of calcium and magnesium on the central nervous system.

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    Main Results:

    • Four out of five patients presented with primarily psychiatric symptoms including depression, catatonia, confusion, disorientation, fatigue, and lethargy.
    • No bone or renal pathology was observed in four of the cases.
    • Literature review supported the link between hyperparathyroidism and neurological/psychiatric disturbances.

    Conclusions:

    • Primary hyperparathyroidism should be considered in the differential diagnosis of unexplained neurological and psychiatric conditions.
    • The role of magnesium in hyperparathyroidism-related central nervous system dysfunction warrants further investigation.