Neonatal halothane anesthesia affects cortical morphology
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Updated: Oct 10, 2026

In Vivo Visualization of Spontaneous Activity in Neonatal Mouse Sensory Cortex at a Single-Neuron Resolution
Published on: November 21, 2023
1Neuroscience Program and Department of Psychology, University of Illinois at Champaign-Urbana, 603 E. Daniel Street, Champaign, IL 61820, USA.
Abstract:
Neonatal cryoanesthesia has recently been documented to affect morphology and behavior after a single exposure [Dev. Brain Res. 111 (1998) 89; Horm. Behav. 37 (2000) 169]. In the current experiment, we investigated the effect of one-time exposure to halothane inhalant anesthesia on neonatal rats of both sexes. Fifteen minutes of exposure on postnatal day one resulted in detectable changes in the volume of the visual cortex at 3 months. Thus, neonatal halothane alters neural development and its effects are observable in the adult rat.
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