Nutraceutical interventions may delay aging and the age-related diseases

Largely due to better control of infectious diseases and to year-round access to a more nutritious diet, life expectancy in developed countries has increased dramatically in the twentieth century. However, as the average age of the population has risen, the incidence of chronic age-related diseases such as Alzheimer's, Parkinson's, cardiovascular disease, cancer, arthritis, osteoporosis, benign prostatic hyperplasia, late-onset diabetes, and macular degeneration have increased. To obtain further significant improvements in both lifespan and the quality of life in this century, treatments and nutritional changes that address the age-related diseases and the aging process itself need to be examined and validated. There are many reports suggesting that oxidative stress and certain nutritional deficiencies may contribute to the aging process and to many age-related diseases. In this article, we report on two human clinical trials using novel antioxidant supplements in which urinary oxidative stress is significantly reduced. We also discuss the conceptual basis and existing literature for several nutritional supplements that may have beneficial effects on aging and age-related diseases. Based on the available data, we suggest that human life expectancy can be significantly increased in the twenty-first century by optimizing diet and using nutritional supplements.