In vitro study on fluoxetine adsorption onto charcoal using potentiometry

Area of Science:

• Pharmacokinetics
• Materials Science
• Analytical Chemistry

Background:

• Fluoxetine (F) overdose requires effective adsorbent materials.
• Activated charcoal and its formulations are commonly used in poisoning cases.
• Understanding adsorption kinetics and capacity is crucial for treatment efficacy.

Purpose of the Study:

• To investigate the adsorption characteristics of fluoxetine to activated charcoal and Carbomix.
• To determine the adsorption rate constant and maximum adsorption capacity in simulated gastric fluid.
• To evaluate the suitability of these charcoals for treating fluoxetine intoxication.

Main Methods:

• In vitro study using simulated gastric fluid (pH 1.2).
• Ion-selective electrode (ISE) potentiometry for real-time fluoxetine monitoring.
• Kinetic experiments measuring drug concentration changes over time.
• Determination of adsorption rate constants and maximum adsorption capacities.

Main Results:

• Both activated charcoal and Carbomix demonstrated rapid adsorption of fluoxetine.
• Carbomix exhibited a higher maximum adsorption capacity (405 mg/g) compared to activated charcoal (254.8 mg/g).
• High adsorption efficiency (95% within 5 min) was observed with sufficient charcoal amounts.

Conclusions:

• Activated charcoal and Carbomix effectively adsorb fluoxetine in simulated gastric conditions.
• Carbomix is a promising charcoal formulation for managing fluoxetine poisoning.
• The study provides valuable data on the adsorption kinetics and capacity of charcoals for fluoxetine.