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Related Experiment Videos

Effects of fasting on hepatic function in ponies.

R Gronwall

    American Journal of Veterinary Research
    |February 1, 1975
    PubMed
    Summary

    Fasting impairs equine hepatic function by decreasing sulfobromophthalein sodium (BSP) removal from plasma. This indicates reduced liver clearance in fasted ponies, affecting overall hepatic clearance.

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    Area of Science:

    • Equine physiology
    • Hepatology
    • Comparative medicine

    Background:

    • Hepatic function is crucial for drug metabolism and detoxification in equids.
    • Sulfobromophthalein sodium (BSP) is a common agent for assessing liver function.
    • Nutritional status, specifically fasting, may influence hepatic metabolic capacity.

    Purpose of the Study:

    • To investigate the impact of fasting on equine hepatic function.
    • To quantify changes in sulfobromophthalein sodium (BSP) clearance and metabolism in ponies under fasting conditions.

    Main Methods:

    • Three experiments were conducted in ponies to assess hepatic function using BSP.
    • Methods included single BSP injections to determine plasma removal rates and half-times (t 1/2).
    • Sustained BSP infusions were used to measure plasma clearance, maximal excretion, and hepatic storage capacity.

    Main Results:

    • Fasting significantly decreased the rate of BSP removal from plasma, evidenced by an increased half-time (t 1/2).
    • BSP clearance from plasma was reduced during fasting.
    • While maximal BSP excretion was unaffected, hepatic storage capacity for BSP was diminished in fasted ponies.

    Conclusions:

    • Fasting leads to a decreased hepatic clearance of BSP in ponies.
    • The results suggest that nutritional status impacts the liver's ability to process and excrete substances.
    • Further research into the mechanisms underlying fasting-induced changes in equine hepatic function is warranted.

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