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Related Experiment Videos

Multiple tissue core arrays in histopathology research: a validation study.

C E Gillett1, R J Springall, D M Barnes

  • 1Hedley Atkins/ICRF Breast Pathology Laboratory, Guy's Hospital, London SE1 9RT, UK.

The Journal of Pathology
|December 13, 2000
PubMed
Summary
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Multicored tissue arrays efficiently analyze large breast cancer cohorts for research. While generally accurate for oestrogen (ER) and progesterone (PR) receptor staining, some cores may not represent the whole tumor.

Area of Science:

  • Oncology
  • Pathology
  • Biotechnology

Background:

  • Tissue arrays enable large-scale tumor tissue examination, saving resources and allowing direct slide comparisons.
  • Assessing biomarkers like oestrogen (ER) and progesterone (PR) receptors is crucial in breast cancer research.

Purpose of the Study:

  • To compare the accuracy of multicore tissue arrays versus whole tissue sections for ER and PR receptor staining in breast cancer.
  • To evaluate the efficiency and representativeness of multicore arrays for large-scale tumor research.

Main Methods:

  • 157 breast cancer samples were analyzed using both whole tissue sections and multicore tissue arrays.
  • Antibodies for ER and PR receptors were used for staining, and scores (0-7) were compared between methods.

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Main Results:

  • A highly significant association was found between staining scores from whole sections and multicore arrays.
  • Discordance in receptor status (positive/negative) was observed in 5% of ER and 6.5% of PR cases.
  • A proportion of individual tissue cores were not representative of the diagnostic whole section.

Conclusions:

  • Multicore tissue arrays offer an efficient method for analyzing large tumor cohorts in research settings, reducing costs and time.
  • While valuable for research, the potential for non-representative cores limits their use in direct patient management.
  • This technique is effective for assessing the predictive value of novel proteins in extensive tumor collections.