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Excretion pattern investigation of urinary normal and modified nucleosides of breast cancer patients by RP-HPLC and
G Xu1, H R Schmid, X Lu
1National Chromatographic R. & A. Center, Dalian Institute of Chemical Physics, the Chinese Academy of Sciences, 116011 Dalian, People's Republic of China. dicp402@mail.lnptt.ln.cn
Abstract:
Modified nucleosides, formed post-transcriptionally in RNA by a number of modification enzymes, are excreted in abnormal levels in the urine of patients with malignant tumors. To test their usefulness as tumor markers, and to compare them with the conventional tumor markers, a reversed-phase high-performance liquid chromatographic (RP-HPLC) method and a factor analysis method have been used to study the excretion pattern of nucleosides of breast cancer patients. A clear cut differentiation of the breast cancer group and the healthy individuals in two clusters without overlapping was obtained.
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