Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

351
 The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
351
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

365
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
365
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

3.2K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.2K
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

2.1K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.1K
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

870
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
870
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

4.9K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
4.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Phenotyping animal models of diabetic neuropathy: a consensus statement of the diabetic neuropathy study group of the EASD (Neurodiab).

Journal of the peripheral nervous system : JPNS·2014
Same author

Diabetic neuropathy: pathogenetic background, current and future therapies.

Expert review of neurotherapeutics·2009
Same author

Human C-peptide dose dependently prevents early neuropathy in the BB/Wor-rat.

International journal of experimental diabetes research·2002
Same author

Proinsulin C-peptide--a consensus statement.

International journal of experimental diabetes research·2002
Same author

Has C-peptide come of age?

International journal of experimental diabetes research·2002
Same author

Clinical characteristics of a family with chromosome 17-linked disinhibition-dementia-parkinsonism-amyotrophy complex. 1994.

Neurology·2002
Same journal

Less Is More? Physical Inactivity and Increased Risk of Diabetes-Related Foot Ulceration-A Systematic Review.

Diabetes/metabolism research and reviews·2026
Same journal

Analysis of Circulating Long Non-Coding RNA in Prediabetes or Newly Diagnosed Type 2 Diabetes Subjects With or Without Heart Stress.

Diabetes/metabolism research and reviews·2026
Same journal

Biomarkers for Diabetic Peripheral Artery Disease: An Integrated Review and Clinical Perspective.

Diabetes/metabolism research and reviews·2026
Same journal

Retinol, Carotenoid, and Tocopherol Intake and Status, and the Risk of Islet Autoimmunity and Type 1 Diabetes: The Environmental Determinants of Diabetes in the Young Study.

Diabetes/metabolism research and reviews·2026
Same journal

Glucokinase Regulatory Protein Gene Polymorphism as a Predictive Biomarker for Early Renal Injury in Newly Diagnosed Early-Onset Type 2 Diabetes Mellitus.

Diabetes/metabolism research and reviews·2026
Same journal

Hearing Loss in Adults With Diabetes and Prediabetes: A Systematic Review and Meta-Analysis.

Diabetes/metabolism research and reviews·2026
See all related articles

Related Experiment Video

Updated: Jan 18, 2026

Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease
08:15

Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease

Published on: May 10, 2024

923

Diabetic neuropathy--a continuing enigma.

K Sugimoto1, Y Murakawa, A A Sima

  • 1Department of Pathology, Wayne State University, School of Medicine and Detroit Medical Center, Detroit, MI 48201, USA.

Diabetes/Metabolism Research and Reviews
|December 13, 2000
PubMed
Summary
This summary is machine-generated.

Diabetic somatic polyneuropathy (DSPN) involves complex pathogenesis and varied clinical presentations. This review covers signs, symptoms, staging, and emerging therapeutic strategies for managing DSPN in diabetes.

More Related Videos

Author Spotlight: Integrating Tai Chi with Mindfulness Training to Achieve an Effective Mind-Body Exercise
05:06

Author Spotlight: Integrating Tai Chi with Mindfulness Training to Achieve an Effective Mind-Body Exercise

Published on: July 14, 2023

2.3K
Three-dimensional Imaging and Analysis of Mitochondria within Human Intraepidermal Nerve Fibers
10:31

Three-dimensional Imaging and Analysis of Mitochondria within Human Intraepidermal Nerve Fibers

Published on: September 29, 2017

10.7K

Related Experiment Videos

Last Updated: Jan 18, 2026

Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease
08:15

Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease

Published on: May 10, 2024

923
Author Spotlight: Integrating Tai Chi with Mindfulness Training to Achieve an Effective Mind-Body Exercise
05:06

Author Spotlight: Integrating Tai Chi with Mindfulness Training to Achieve an Effective Mind-Body Exercise

Published on: July 14, 2023

2.3K
Three-dimensional Imaging and Analysis of Mitochondria within Human Intraepidermal Nerve Fibers
10:31

Three-dimensional Imaging and Analysis of Mitochondria within Human Intraepidermal Nerve Fibers

Published on: September 29, 2017

10.7K

Area of Science:

  • Neurology
  • Endocrinology
  • Diabetology

Background:

  • Diabetic somatic polyneuropathy (DSPN) is a common complication of diabetes mellitus.
  • Its pathogenesis is complex and not fully understood, with variations between type 1 and type 2 diabetes.
  • Heterogeneity in neuropathology and natural history complicates disease management.

Purpose of the Study:

  • To review the clinical manifestations, prevalence, and management of DSPN.
  • To discuss advancements in understanding DSPN pathogenesis and neuropathology.
  • To summarize therapeutic trial results and explore future treatment avenues.

Main Methods:

  • Literature review of clinical signs, symptoms, and prevalence of DSPN.
  • Analysis of various staging and classification systems for DSPN.
  • Summary of findings from therapeutic clinical trials for DSPN.
  • Discussion of recent advances in understanding diabetic neuropathy, differentiating between diabetes types.

Main Results:

  • DSPN presents with diverse clinical signs and symptoms.
  • Multiple staging paradigms exist, highlighting disease complexity.
  • Therapeutic trial outcomes vary, indicating a need for further research.
  • Understanding of DSPN pathogenesis is evolving, with key differences noted between diabetes types.

Conclusions:

  • DSPN is a heterogeneous condition requiring comprehensive clinical management.
  • Continued research into pathogenesis and neuropathology is crucial for developing effective therapies.
  • Exploring novel therapeutic avenues is essential for improving patient outcomes in DSPN.