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Updated: Aug 15, 2026

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
Published on: August 11, 2015
Regional cerebral blood flow changes in drug-resistant depressed patients following treatment with transcranial
1School of Clinical Sciences, Faculty of Health Studies, Charles Sturt University, Locked Bag 588, NSW 2678, Wagga Wagga, Australia. xzheng@csu.edu.au
Abstract:
Changes of regional cerebral blood flow (rCBF) in five drug-resistant depressed patients were examined by single photon emission computed tomography (SPECT) with 99mTc-hexamethylpropyleneamine oxime (99mTc-HMPAO) before and after treatment with transcranial magnetic stimulation (TMS). The SPECT images were analysed with the Statistical Parametric Mapping (SPM) package. TMS administered in the region of the left dorsolateral prefrontal cortex (DLPFC) of the depressed patients was associated with an increase of rCBF at a focal region some distance from the stimulation site. No change was observed at any other remote region.

