Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Caspases: key players in programmed cell death.

M G Grütter1

  • 1Institute of Biochemistry, University of Zürich, Winterthurerstrasse 190, 8057, Zürich, Switzerland. gruetter@biocfebs.unizh.ch

Current Opinion in Structural Biology
|December 15, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A series of Fas receptor agonist antibodies that demonstrate an inverse correlation between affinity and potency.

Cell death and differentiation·2012
Same author

Generation of human TRIM5alpha mutants with high HIV-1 restriction activity.

Gene therapy·2010
Same author

Studies of the molecular mechanism of caspase-8 activation by solution NMR.

Cell death and differentiation·2009
Same author

nDsbD: a redox interaction hub in the Escherichia coli periplasm.

Cellular and molecular life sciences : CMLS·2006
Same author

Zooming in on the hydrophobic ridge of H-2D(b): implications for the conformational variability of bound peptides.

Journal of molecular biology·2001
Same author

Crystal structure of neuroserpin: a neuronal serpin involved in a conformational disease.

FEBS letters·2001

Caspase research reveals enzyme structures and functions, aiding understanding of apoptosis and guiding the development of targeted therapies for related diseases.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Structural Biology

Background:

  • Apoptosis research highlights the critical role of caspases.
  • Understanding caspase structure and function is key to cellular processes.

Purpose of the Study:

  • To elucidate the structure, function, and specificity of key caspases.
  • To provide a foundation for understanding caspase roles in disease.
  • To guide the design of selective caspase inhibitors.

Main Methods:

  • Determination of the three-dimensional structures of caspase-1, caspase-3, and caspase-8.
  • Biochemical studies to analyze enzyme activity and specificity.

Main Results:

  • Detailed structural information for caspase-1, caspase-3, and caspase-8 has been obtained.

Related Experiment Videos

  • Biochemical data has enhanced the understanding of caspase function and specificity.

    • Conclusions:

    • Structural and biochemical insights into caspases are crucial for biological role elucidation.
    • This knowledge facilitates the design of targeted inhibitors for caspase-mediated diseases.