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Updated: Aug 19, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Efficacy of intravenous clindamycin and methicillin in gram-positive soft tissue infections

K C Chessick, L A Begley, L E Curtis

    Annals of Surgery
    |February 1, 1975
    PubMed

    Insights

    Clindamycin phosphate and methicillin effectively treated soft tissue infections caused by gram-positive bacteria. Both antibiotics showed comparable efficacy and adverse effects, making clindamycin a viable alternative to methicillin.

    Area of Science:

    • Infectious Diseases
    • Pharmacology
    • Surgical Infections

    Background:

    • Soft tissue infections caused by gram-positive organisms, particularly staphylococci, are common in general surgery.
    • Effective antibiotic therapy is crucial as an adjunct to surgical management.

    Purpose of the Study:

    • To compare the efficacy and safety of intravenous clindamycin phosphate versus methicillin in treating soft tissue infections.
    • To evaluate clindamycin phosphate as a potential substitute for methicillin.

    Main Methods:

    • A comparative study was conducted on a general surgical service.
    • Patients received either intravenous clindamycin phosphate or methicillin.
    • Infections were classified by severity, causative organisms (gram-positive, chiefly staphylococci), and site.

    Main Results:

    • Both clindamycin and methicillin demonstrated excellent or good clinical and bacteriologic responses.
    • Adverse effects for both drugs were comparable.
    • Clindamycin phosphate proved effective as an adjunct to surgical therapy.

    Conclusions:

    • Clindamycin phosphate is a satisfactory alternative to methicillin for treating soft tissue infections.
    • The study supports the use of clindamycin phosphate in managing gram-positive soft tissue infections.

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