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Related Experiment Videos

Is calciphylaxis best treated surgically or medically?

A S Kang1, J T McCarthy, C Rowland

  • 1Division of Gastroenterologic and General Surgery, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA.

Surgery
|December 15, 2000
PubMed
Summary
This summary is machine-generated.

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Calciphylaxis, a severe skin necrosis condition in uremia patients, has a poor prognosis. Intensive treatment including hemodialysis and debridement is recommended, but parathyroidectomy is not routinely advised.

Area of Science:

  • Nephrology
  • Dermatology
  • Endocrinology

Background:

  • Calciphylaxis is a rare, painful condition causing skin necrosis and poor healing in patients with uremia and secondary hyperparathyroidism.
  • Pathogenesis involves abnormal calcium and phosphorus metabolism with tissue calcium deposition.

Purpose of the Study:

  • To review the clinical course and outcomes of patients diagnosed with calciphylaxis.
  • To evaluate the effectiveness of various treatment modalities.

Main Methods:

  • Retrospective review of 16 patients diagnosed with calciphylaxis between 1994 and 1998.
  • Analysis of intensive medical therapy including hemodialysis, parathyroidectomy, and debridement.

Main Results:

  • The study included 14 females and 2 males with chronic renal disease, secondary hyperparathyroidism, and skin necrosis.

Related Experiment Videos

  • Median survival was 9.4 months, with 93% mortality.
  • Survival showed trends favoring parathyroidectomy and debridement, but not statistically significant.

    • Conclusions:

    • Calciphylaxis predominantly affects females and has a very poor prognosis.
    • A multidisciplinary approach with hemodialysis and debridement is recommended.
    • Parathyroidectomy should be reserved for cases with severe hyperparathyroidism.