Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Janus kinases: components of multiple signaling pathways.

S G Rane1, E P Reddy

  • 1Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, 3307 N. Broad Street, Philadelphia, Pennsylvania, PA 19140, USA.

Oncogene
|December 15, 2000
PubMed
Summary

Janus kinases (JAKs) are vital for cell signaling, regulating survival and growth. Proper JAK activity is essential for transmitting cytokine and growth factor signals, with dysregulation linked to diseases like cancer and immunodeficiency.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Editorial Expression of Concern: Disruption of transforming growth factor-β signaling through β-spectrin ELF leads to hepatocellular cancer through cyclin D1 activation.

Oncogene·2026
Same author

Correction: critical interactions between TGF-β signaling/ELF, and E-cadherin/β-catenin mediated tumor suppression.

Oncogene·2021
Same author

Effect of Semicarpus anacardium on the cell cycle of DU-145 cells.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2012
Same author

Lipid abnormalities, lipoprotein (a) and apoprotein pattern in non-dialyzed patients with chronic kidney disease.

Indian journal of clinical biochemistry : IJCB·2012
Same author

New Therapeutics Targeting Colon Cancer Stem Cells.

Current colorectal cancer reports·2010
Same author

Styryl sulfonyl compounds inhibit translation of cyclin D1 in mantle cell lymphoma cells.

Oncogene·2009

Area of Science:

  • Cellular Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Cytoplasmic Janus kinases (JAKs) are key regulators of signal transduction pathways.
  • JAKs influence cellular survival, proliferation, differentiation, and apoptosis.
  • JAKs integrate diverse signaling cascades, including STAT protein activation.

Purpose of the Study:

  • To elucidate the primary functions of JAK kinases in cellular signaling.
  • To investigate the role of JAKs in receptor phosphorylation and downstream signaling.
  • To understand the implications of JAK kinase activity aberrations in disease.

Main Methods:

  • The study reviews existing evidence on JAK kinase function and signaling pathways.
  • It focuses on JAK-mediated phosphorylation of cytokine and growth factor receptors.

Related Experiment Videos

  • The research examines the requirement of JAKs for downstream signaling cascades like Src, Ras-MAPK, PI3K-AKT, and STAT.

    • Main Results:

    • Emerging evidence suggests JAKs primarily function by phosphorylating cytokine and growth factor receptors.
    • This JAK-triggered receptor phosphorylation is a critical, potentially rate-limiting, step for downstream signaling.
    • JAK kinase activity is essential for optimal activation of Src, Ras-MAPK, PI3K-AKT, and STAT pathways.

    Conclusions:

    • Optimal JAK kinase activity is crucial for the normal transmission of cytokine and growth factor signals.
    • Aberrant JAK activity, either overactivation or loss of function, is linked to significant disease states.
    • Overactivation of JAKs is implicated in tumorigenesis, while loss of function causes severe-combined immunodeficiency.