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Hansenula anomala infection in a neonate

A R Wong1, H Ibrahim, H Van Rostenberghe

  • 1Department of Paediatrics, School of Medical Sciences, University Sains Malaysia, Kelantan. rahim@kck.usm.my

Journal of Paediatrics and Child Health
|December 15, 2000
PubMed

Insights

A rare Hansenula anomala fungal infection occurred in a premature infant after surgery. Standard amphotericin B treatment failed, but oral ketoconazole successfully eradicated the yeast.

Area of Science:

  • Neonatal Medicine
  • Infectious Diseases
  • Mycology

Background:

  • Neonatal fungal infections pose significant risks, especially in very low birthweight infants.
  • Omphalocele repair surgery can increase susceptibility to infections in neonates.

Observation:

  • A very low birthweight infant developed an unusual fungal infection caused by Hansenula anomala following abdominal surgery.
  • The infant presented with persistent fungemia despite initial antifungal therapy.

Findings:

  • Standard treatment with amphotericin B was ineffective in eradicating Hansenula anomala.
  • Oral ketoconazole proved successful in clearing the yeast from blood cultures.

Implications:

  • This case highlights the potential for unusual fungal pathogens in neonatal intensive care units.
  • Alternative or combination antifungal strategies may be necessary for refractory neonatal fungal infections.
  • Early identification and tailored treatment are crucial for managing invasive fungal infections in vulnerable neonates.

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