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A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
Published on: June 24, 2020
Hansenula anomala infection in a neonate
A R Wong1, H Ibrahim, H Van Rostenberghe
1Department of Paediatrics, School of Medical Sciences, University Sains Malaysia, Kelantan. rahim@kck.usm.my
Journal of Paediatrics and Child Health
|December 15, 2000
Summary
A rare Hansenula anomala fungal infection occurred in a premature infant after surgery. Standard amphotericin B treatment failed, but oral ketoconazole successfully eradicated the yeast.
Area of Science:
- Neonatal Medicine
- Infectious Diseases
- Mycology
Background:
- Neonatal fungal infections pose significant risks, especially in very low birthweight infants.
- Omphalocele repair surgery can increase susceptibility to infections in neonates.
Observation:
- A very low birthweight infant developed an unusual fungal infection caused by Hansenula anomala following abdominal surgery.
- The infant presented with persistent fungemia despite initial antifungal therapy.
Findings:
- Standard treatment with amphotericin B was ineffective in eradicating Hansenula anomala.
- Oral ketoconazole proved successful in clearing the yeast from blood cultures.
Implications:
- This case highlights the potential for unusual fungal pathogens in neonatal intensive care units.
- Alternative or combination antifungal strategies may be necessary for refractory neonatal fungal infections.
- Early identification and tailored treatment are crucial for managing invasive fungal infections in vulnerable neonates.
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