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Published on: December 6, 2016
Measuring quality of life in children with obstructive sleep disorders
L M de Serres1, C Derkay, S Astley
1Division of Pediatric Otolaryngology, Children's Hospital and Regional Medical Center, University of Washington, Seattle, USA. LMD54@columbia.edu
Insights
The OSD-6 instrument reliably measures health-related quality of life in children with obstructive sleep disorders (OSDs). This validated tool effectively detects changes after adenotonsillectomy, improving patient care.
Area of Science:
- Pediatric Otolaryngology
- Sleep Medicine
- Quality of Life Research
Background:
- Obstructive sleep disorders (OSDs) significantly impact children's health-related quality of life (HRQOL).
- Validated disease-specific instruments are crucial for assessing HRQOL in pediatric OSD patients.
Purpose of the Study:
- To validate a disease-specific HRQOL instrument, the OSD-6, for children diagnosed with obstructive sleep disorders.
- To assess the reliability, validity, and responsiveness of the OSD-6 in pediatric patients.
Main Methods:
- A prospective cohort study involving 100 caregivers of children (ages 2-12) with OSDs secondary to adenotonsillar hypertrophy.
- The 6-item Obstructive Sleep Disorder-6 (OSD-6) instrument was administered at baseline and post-adenotonsillectomy.
- Test-retest reliability, internal consistency, construct validity, and responsiveness were evaluated.
Main Results:
- The OSD-6 demonstrated good test-retest reliability (ICC = 0.74).
- Construct validity was supported by correlations with global QOL measures (R = -0.62 to -0.63).
- The instrument showed large responsiveness to clinical change post-surgery (standardized response = 2.3).
Conclusions:
- The OSD-6 is a reliable, valid, and responsive instrument for assessing HRQOL in children with OSDs.
- It is suitable for detecting clinical changes following adenotonsillectomy.
- The OSD-6 is easily administered and valuable for clinical practice.
Objective:
To validate a disease-specific health-related quality of life (HRQOL) instrument for children with obstructive sleep disorders (OSDs).
Design:
Prospective cohort study using a 6-item health-related instrument (OSD-6).
Subjects:
One hundred caregivers of patients with OSDs secondary to adenotonsillar hypertrophy (age range, 2-12 years) from 2 tertiary care, pediatric otolaryngology practices.
Intervention:
The OSD-6 was administered on initial presentation and 4 to 5 weeks after adenotonsillectomy. A subset of patients repeated the OSD-6 within 3 weeks after presentation to assess test-retest reliability.
Main Outcome Measures:
Test-retest reliability, internal consistency, construct validity, and responsiveness to clinical change of the OSD-6 score.
Results:
Test-retest reliability was good (intraclass correlation coefficient = 0.74). Median OSD-6 score was 4.5 (0- to 6-point scale) with higher scores indicating poorer quality of life (QOL). Construct validity was demonstrated by the moderate correlation between OSD-6 score and global adenoid and tonsil-related QOL (R = -0.62), strong correlation between the OSD-6 change score and change in global adenoid and tonsil-related QOL (R = -0.63), and the moderate correlation between the change score and parent estimate of clinical change (R = 0.40). The mean change in OSD-6 score after adenotonsillectomy was 3.0 (95% confidence interval, 2.7-3.4). The mean standardized response was 2.3 (95% confidence interval, 1.9-2.7) indicating the instrument's large responsiveness to clinical change. The change score was very reliable (R = 0.85).
Conclusions:
The OSD-6 is a reliable, responsive, easily administered instrument. It is valid for detecting change after adenotonsillectomy in children with OSDs. Arch Otolaryngol Head Neck Surg. 2000;126:1423-1429
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