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A genome scan for renal function among hypertensives: the HyperGEN study.
A T DeWan1, D K Arnett, L D Atwood
1Division of Epidemiology, University of Minnesota, Minneapolis, MN 55454, USA.
American Journal of Human Genetics
|December 15, 2000
Summary
Genetic factors influence kidney function in hypertension. This study identified a region on chromosome 3 linked to creatinine clearance variability in African American and white hypertensive individuals, suggesting specific genetic contributions to renal function.
Area of Science:
- Genetics
- Nephrology
- Cardiovascular Disease Epidemiology
Background:
- Hypertension frequently leads to decreased renal function.
- The genetic basis for kidney function variability in hypertension is not well understood.
- Creatinine clearance is a key indicator of kidney function.
Purpose of the Study:
- To investigate the genetic contribution to creatinine clearance variability in hypertensive individuals.
- To identify specific genetic regions associated with renal function in a biracial hypertensive cohort.
Main Methods:
- Utilized data from the Hypertension Genetic Epidemiology Network (HyperGEN) study.
- Assessed creatinine clearance in African American and white hypertensive siblings.
- Performed multipoint variance components linkage analysis using GENEHUNTER2.
Main Results:
- Heritability of residual creatinine clearance was 17% in African Americans and 18% in whites.
- Significant linkage evidence for creatinine clearance was found on chromosome 3 in both racial groups.
- Candidate genes EHHADH and ApoD are located within the linked region on chromosome 3.
Conclusions:
- Genetic factors play a role in the variability of creatinine clearance among hypertensive individuals.
- Chromosome 3 harbors genetic regions influencing renal function in hypertension.
- Identified positional candidate genes warrant further investigation for their role in hypertensive nephropathy.