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Related Experiment Videos

A genome scan for renal function among hypertensives: the HyperGEN study.

A T DeWan1, D K Arnett, L D Atwood

  • 1Division of Epidemiology, University of Minnesota, Minneapolis, MN 55454, USA.

American Journal of Human Genetics
|December 15, 2000
PubMed
Summary

Genetic factors influence kidney function in hypertension. This study identified a region on chromosome 3 linked to creatinine clearance variability in African American and white hypertensive individuals, suggesting specific genetic contributions to renal function.

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Area of Science:

  • Genetics
  • Nephrology
  • Cardiovascular Disease Epidemiology

Background:

  • Hypertension frequently leads to decreased renal function.
  • The genetic basis for kidney function variability in hypertension is not well understood.
  • Creatinine clearance is a key indicator of kidney function.

Purpose of the Study:

  • To investigate the genetic contribution to creatinine clearance variability in hypertensive individuals.
  • To identify specific genetic regions associated with renal function in a biracial hypertensive cohort.

Main Methods:

  • Utilized data from the Hypertension Genetic Epidemiology Network (HyperGEN) study.
  • Assessed creatinine clearance in African American and white hypertensive siblings.
  • Performed multipoint variance components linkage analysis using GENEHUNTER2.

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Main Results:

  • Heritability of residual creatinine clearance was 17% in African Americans and 18% in whites.
  • Significant linkage evidence for creatinine clearance was found on chromosome 3 in both racial groups.
  • Candidate genes EHHADH and ApoD are located within the linked region on chromosome 3.

Conclusions:

  • Genetic factors play a role in the variability of creatinine clearance among hypertensive individuals.
  • Chromosome 3 harbors genetic regions influencing renal function in hypertension.
  • Identified positional candidate genes warrant further investigation for their role in hypertensive nephropathy.