Chemical kindling and seizure susceptibility in morphine dependent rats

N Atapour¹, T P Kalantaripour, M Nourpanah

¹Neuroscience Research Center, Kerman University of Medical Sciences, P.O. Box 76175-113, Kerman, Iran. atapour@yahoo.com

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology

|December 15, 2000

Abstract:

In the present study, we investigated whether and how chronic morphine administration changes seizure susceptibility in rats. The role of morphine-dependence on the seizure susceptibility has been evaluated with models of pentylenetetrazol (PTZ)-kindling and acute convulsions induced by PTZ, N-methyl-D-aspartic acid (NMDA), picrotoxin and caffeine in adult male rats. The results showed that morphine-dependence increased seizure severity only at 1-4th PTZ injections in the kindling model. In acute convulsion tests, dependent rats demonstrated a significantly lower seizure threshold only for PTZ, while they demonstrated a significantly lower tendency to show tonic-clonic convulsions only for NMDA. It is concluded that morphine-dependence may modulate PTZ-kindling and seizure susceptibility in rats with emphasis on the role of GABA and NMDA neurotransmitter systems.

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Abstract:

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