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Related Experiment Videos

Viral replication and the coactivators p300 and CBP.

M O Hottiger1, G J Nabel

  • 1Institute of Veterinary Biochemistry, The University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.

Trends in Microbiology
|December 15, 2000
PubMed
Summary

Viruses hijack cellular gene expression using viral proteins that interact with transcriptional coactivators like p300 and CBP. This interaction impacts cell differentiation and proliferation, crucial for productive viral infection.

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Area of Science:

  • Molecular biology
  • Virology
  • Cellular biology

Background:

  • Productive viral infection depends on coordinated viral and cellular gene expression.
  • Viruses adapt to and exploit host cell gene expression programs.
  • Cellular differentiation and proliferation are regulated by specific signaling pathways.

Purpose of the Study:

  • To summarize molecular interactions between viral proteins and transcriptional coactivators.
  • To review how DNA tumor viruses and lentiviruses interact with p300 and CBP.
  • To understand viral exploitation of host cell machinery.

Main Methods:

  • Literature review of molecular interactions.
  • Analysis of viral protein functions.
  • Examination of coactivator roles in gene regulation.

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Main Results:

  • Viral proteins from DNA tumor viruses and lentiviruses interact with p300 and CBP.
  • These interactions influence chromatin structure and cell cycle progression.
  • Coactivators play a central role in regulating genes controlling cell differentiation and proliferation.

Conclusions:

  • Viral interactions with coactivators like p300/CBP are key to productive infection.
  • Understanding these interactions provides insights into viral pathogenesis.
  • Targeting these interactions could offer novel antiviral strategies.