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DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat

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Only fibres promoting a stable butyrate producing colonic ecosystem decrease the rate of aberrant crypt foci in rats.

P Perrin¹, F Pierre, Y Patry

¹Human Nutrition Research Centre of Nantes, INSERM U419, Institut de Biologie, 9 quai Moncousu, 44035 Nantes Cedex 01, France. pperrin@nantes.inserm.fr

|December 15, 2000

Summary

Certain dietary fibers that promote butyrate production in the colon may offer protection against colon cancer. This study found that resistant starch (RS) and fructo-oligosaccharides (FOS) led to fewer aberrant crypt foci in rats, suggesting a reduced susceptibility to colon cancer.

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Published on: July 31, 2019

Area of Science:

Gastroenterology
Nutritional Science
Oncology

Background:

Dietary fibers are investigated for their potential role in colon cancer prevention, but existing research yields inconclusive results.
The protective effects of dietary fibers may be specifically linked to their ability to produce butyrate.

Purpose of the Study:

To investigate the factors necessary for sustained, stable butyrate production in the colon.
To examine the relationship between stable butyrate production and susceptibility to colon cancer.

Main Methods:

A two-part randomized blinded study in rats was conducted using a control diet and three high-fiber diets: wheat bran (WB), resistant starch (RS), and fructo-oligosaccharides (FOS).
Rats were fed diets for varying durations (2-44 days) to assess adaptation, fermentation, and colonic effects, including mucosal proliferation.
A subsequent experiment involved carcinogen injection (azoxymethane) to evaluate aberrant crypt foci formation.

Main Results:

After 44 days, resistant starch (RS) and fructo-oligosaccharides (FOS) diets resulted in significant butyrate production and a trophic effect in the large intestine.
No significant differences in mucosal proliferation were observed among diets at 44 days.
Rats fed high butyrate-producing diets (RS and FOS) exhibited significantly fewer aberrant crypt foci, indicating reduced colon cancer susceptibility.

Conclusions:

A stable colonic ecosystem that produces butyrate, fostered by specific fibers like RS and FOS, appears to inhibit colon carcinogenesis.
These findings support the hypothesis that butyrate-producing fibers play a crucial role in colon cancer prevention.