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Life's 24-hour clock: molecular control of circadian rhythms in animal cells
1Laboratory of Genetics, The Rockefeller University, 1230 York Ave, New York, NY 10021, USA. young@rockvax.rockefeller.edu
Trends in Biochemical Sciences
|December 16, 2000
Abstract:
Our sleep-wake cycles and many other approximately 24-hour rhythms of behavior and physiology persist in the absence of environmental cues. Genetic and biochemical studies have shown that such rhythms are controlled by internal molecular clocks. These are assembled from the cycling RNA and protein products of a small group of genes that are conserved throughout the animal kingdom.