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Related Concept Videos

X-ray Crystallography02:18

X-ray Crystallography

24.8K
The size of the unit cell and the arrangement of atoms in a crystal may be determined from measurements of the diffraction of X-rays by the crystal, termed X-ray crystallography.
Diffraction
Diffraction is the change in the direction of travel experienced by an electromagnetic wave when it encounters a physical barrier whose dimensions are comparable to those of the wavelength of the light. X-rays are electromagnetic radiation with wavelengths about as long as the distance between neighboring...
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X-ray Diffraction of Biological Samples01:10

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X-ray diffraction or XRD is an analytical tool that utilizes X-rays to study ordered structures such as crystalline organic and inorganic samples, polycrystalline materials, proteins, carbohydrates, and drugs.
According to Bragg's law, when X-rays strike the sample positioned on a stage, the rays are  scattered by the electron clouds around the sample atoms. The  X-ray diffraction or scattering is caused by constructive interference of the X-ray waves that reflect off the internal...
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Fixed Target Serial Data Collection at Diamond Light Source
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Synchrotron crystallography.

W A Hendrickson1

  • 1Dept of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University, New York, NY 10032, USA. wayne@convex.hhmi.columbia.edu

Trends in Biochemical Sciences
|December 16, 2000
PubMed
Summary
This summary is machine-generated.

X-ray crystallography has rapidly advanced due to synchrotron radiation, enabling detailed atomic structures. Future developments promise further expansion in structural genomics and macromolecular studies.

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Area of Science:

  • Biophysics
  • Structural Biology
  • Biochemistry

Background:

  • Atomic-level structural determination has seen significant growth over the past decade.
  • This expansion is largely attributed to advances in X-ray crystallography and synchrotron radiation.

Purpose of the Study:

  • To highlight the impact of synchrotron radiation on the growth of X-ray crystallography.
  • To project the future expansion of synchrotron crystallography.

Main Methods:

  • X-ray crystallography
  • Synchrotron radiation
  • Technical advancements in structural determination

Main Results:

  • Explosive growth in atomic-level structures determined by X-ray crystallography in the last decade.
  • Synchrotron radiation and related technical advances have been key drivers of this growth.
  • New resources and collective application of recent advances are paving the way for future expansion.

Conclusions:

  • The foundation is set for a dramatic expansion of synchrotron crystallography in the coming decade.
  • High-throughput structural genomics and complex macromolecular machinery studies are expected to flourish.
  • Continued advancements in synchrotron technology will further accelerate discoveries in structural biology.