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Updated: Aug 2, 2026

Development, Characterization, and Evaluation of CAGE-based Ionic Liquid Systems for Transdermal Delivery
Published on: September 26, 2025
Non-invasive administration of drugs through the skin: challenges in delivery system design
1College of Pharmacy and Nutrition, University of Saskatchewan, PharmaDerm Laboratories, Downey Road, SK S7N 5C9, Saskatoon, Canada
Abstract:
Vehicles designed to enhance drug delivery through the skin must incorporate specific elements that improve the ability of the delivery system to overcome the barrier posed by the stratum corneum. This review discusses several chemical penetration enhancers that have been investigated as potential tools to increase drug flux. In addition, lipid-based delivery systems offer an attractive alternative to traditional drug vehicles. The relationship between liposome composition and drug permeation is discussed, in addition to the possible mechanism of action of lipid vesicle-mediated drug delivery.
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