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Transdermal testing: practical aspects and methods.

El-Kattan¹, Asbill, Haidar

¹Pfizer Global Research and Development, PDM Discovery and Preclinical Development Pharmacokinetics, 48198, Ann Arbor, MI, USA

Pharmaceutical Science & Technology Today

|December 16, 2000

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Transdermal drug delivery offers advantages over other administration routes. Effective evaluation requires careful selection of skin models, mathematical models, and diffusion apparatus for drug permeation studies.

Area of Science:

Pharmacology
Biomedical Engineering
Materials Science

Background:

Transdermal drug delivery systems (TDDS) are gaining prominence due to their numerous benefits compared to conventional administration methods.
Evaluating the efficacy and safety of TDDS requires a comprehensive approach to understanding drug permeation through the skin.

Purpose of the Study:

To highlight the critical factors for effective transdermal product evaluation.
To outline the key considerations for selecting appropriate methodologies in transdermal drug permeation studies.

Main Methods:

Discussion of various skin models (e.g., in vitro, ex vivo, in vivo) for assessing drug permeation.
Review of mathematical modeling techniques to characterize drug diffusion kinetics across biological membranes.

Related Experiment Videos

Examination of different diffusion apparatus designs used in permeation studies.

Main Results:

The choice of skin model significantly impacts the predictability of in vivo performance.
Mathematical models provide essential insights into drug diffusion mechanisms and release rates.
Appropriate diffusion apparatus ensures reliable and reproducible permeation data.

Conclusions:

Effective transdermal product evaluation hinges on the synergistic integration of suitable skin models, robust mathematical characterization, and appropriate diffusion apparatus.
Addressing these three core issues is crucial for advancing the development and application of transdermal drug delivery technologies.