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Updated: Jul 11, 2026
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Electrochemotherapy of Tumours
Published on: December 15, 2008
Damage induction by direct electric current in tumoural target cells
C Holandino1, V F Veiga, M M Capella
1Departamento de Medicamentos-Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Indian Journal of Experimental Biology
|December 16, 2000
Summary
Direct electric current (DC) damages tumour cells, reducing viability and causing membrane damage. This research explores DC
Area of Science:
- Oncology
- Biophysics
- Cell Biology
Background:
- Tumour progression presents significant challenges in treatment.
- Electrochemical therapy is an emerging modality for cancer treatment.
Purpose of the Study:
- To investigate the effects of direct electric current (DC) on tumour target cells (P815).
- To elucidate the cellular mechanisms underlying DC-induced tumour cell damage.
Main Methods:
- Treatment of P815 cells with direct electric current (DC) for 6 minutes.
- Assessment of cell viability and proliferation post-treatment.
- Ultrastructural analysis using microscopy to observe cellular changes.
Main Results:
- DC treatment significantly decreased P815 cell viability and proliferation.
- Ultrastructural analysis revealed membrane blebbing, filopodia loss, and ruptures.
- Mitochondrial alterations, cell swelling, and cytoplasmic changes were observed.
Conclusions:
- Direct electric current effectively damages tumour target cells.
- DC-induced cellular damage provides insights into electrochemical therapy mechanisms.
- This study supports the potential of DC in understanding tumour regression.
