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[Blood coagulation in man during a 3-week daily rg L(+)-ASCORBIC ACID ADMINISTRATION]
Blut
|January 1, 1975
Summary
A daily intake of 4g L (+) ascorbic acid for three weeks did not affect blood coagulation in healthy men. Thromboelastography analysis confirmed no significant changes in key coagulation parameters.
Area of Science:
- Biochemistry
- Hematology
- Clinical Nutrition
Context:
- Ascorbic acid (Vitamin C) is a vital nutrient with antioxidant properties.
- Its potential impact on hemostasis and blood coagulation requires further investigation.
- Understanding Vitamin C's role in coagulation is crucial for clinical applications.
Purpose:
- To evaluate the effect of a high daily dose of L (+) ascorbic acid on venous blood coagulation parameters.
- To assess changes in coagulation using thromboelastography in healthy adult males.
Summary:
- A 3-week daily administration of 4g L (+) ascorbic acid was studied in 11 healthy men.
- Thromboelastography was used to measure 7 coagulation parameters.
- No statistically significant changes were observed in any coagulation parameters before and after ascorbic acid supplementation.
Impact:
- This study suggests that high-dose L (+) ascorbic acid supplementation does not significantly alter blood coagulation in healthy individuals.
- Findings contribute to the understanding of Vitamin C's physiological effects beyond its antioxidant role.
- Provides baseline data for future research on ascorbic acid and hemostasis in different populations or conditions.