[Blood coagulation in man during a 3-week daily rg L(+)-ASCORBIC ACID ADMINISTRATION]

A daily dose of 4 g L (+) ascorbic acid administered for 3 weeks showed no significant influence on coagulation of venous blood, as determined by thromboelastography. The investigation was carried out on 11 healthy men aged from 25 to 45 with no history of abnormal blood clotting. The mean values of 7 different coagulation parameters are given, the differences in these parameters in individual subjects (before and after administration of ascorbic acid) being checked for significance by means of the Wilcoxon test for pair differences. The values found are comparable with those in the literature.