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Related Experiment Videos

The variability of serial fMRI data: correlation between a visual and a motor task.

D Waldvogel1, P van Gelderen, I Immisch

  • 1Human Motor Control Section, NINDS, NIH, Bethesda, MD 20892-1428, USA.

Neuroreport
|December 16, 2000
PubMed
Summary

Serial functional MRI (fMRI) studies show significant intersession variability in activation. This variability, influenced by global brain factors, limits the reliability of using standardized tasks for data normalization due to unpredictable outliers.

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Area of Science:

  • Neuroimaging
  • Cognitive Neuroscience
  • Functional Magnetic Resonance Imaging (fMRI)

Background:

  • Serial functional magnetic resonance imaging (fMRI) studies are crucial for tracking brain changes over time.
  • Understanding intersession variability is essential for reliable longitudinal fMRI research.
  • Variability may stem from task-specific or global factors affecting brain activity.

Purpose of the Study:

  • To investigate the correlation of intersession variability between standardized visual and motor tasks in serial fMRI.
  • To assess the impact of global factors on brain activation variability across multiple scanning sessions.
  • To determine the utility of standardized tasks for normalizing fMRI data in longitudinal studies.

Main Methods:

  • Six healthy volunteers underwent repeated fMRI scans at weekly intervals.

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  • Standardized visual and motor tasks were employed during all scanning sessions.
  • Analysis focused on the number of activated pixels and activation amplitude.
  • Correlation of variability patterns between the two task modalities was assessed.

    • Main Results:

    • Significant intersession variability was observed in both the number of activated pixels (up to 1150% difference) and activation amplitude (up to 250% difference).
    • Three participants exhibited a high correlation in variability between visual and motor tasks.
    • The remaining three participants showed at least one outlier session, disrupting the correlation.
    • Variability appears to be influenced by global factors affecting overall brain activity.

    Conclusions:

    • Intersession variability in serial fMRI is substantial and likely driven by global physiological or environmental factors.
    • The presence of unpredictable outliers significantly limits the effectiveness of using standardized tasks for normalizing fMRI data.
    • Researchers should exercise caution when using standardized tasks for data normalization in longitudinal fMRI studies.