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Adrenarche and nutritional status.

T Remer1

  • 1Department of Nutrition and Health, Research Institute of Child Nutrition Dortmund at the University Witten/Herdecke, Germany. remer@fke.uni-dortmund.de

Journal of Pediatric Endocrinology & Metabolism : JPEM
|December 16, 2000
PubMed
Summary
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Nutritional status influences adrenal androgen secretion during childhood. Rising body mass index in children correlates with increased dehydroepiandrosterone sulfate (DHEAS) excretion, suggesting nutrition regulates adrenarche.

Area of Science:

  • Pediatric Endocrinology
  • Human Physiology
  • Nutritional Science

Background:

  • The prepubertal fat spurt and adrenarche onset correlate with elevated insulin and IGF-I.
  • Adrenal cortex receptors for anabolic peptides suggest nutritional status influences adrenal function.

Purpose of the Study:

  • To investigate the causal role of nutritional status in regulating adrenal androgen secretion in children.
  • To test the hypothesis that nutritional status causally affects adrenarche.

Main Methods:

  • Longitudinal study of healthy, normal-weight prepubertal and pubertal children over at least 4 years.
  • Measurement of anthropometric indices for nutritional status.
  • Quantification of 24-hour urinary dehydroepiandrosterone sulfate (DHEAS) excretion rates.

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Main Results:

  • Increases in urinary DHEAS excretion were significantly elevated during periods of highest individual rise in body mass index.
  • Demonstrated a significant correlation between changes in nutritional status and DHEAS excretion.

Conclusions:

  • Provides the first in vivo evidence that nutritional status is a key physiological regulator of adrenarche.
  • Suggests that nutritional status plays a critical role in the timing and progression of adrenarche.