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Related Experiment Videos

The gonadotropic axis in hyperandrogenic adolescents.

A E Taylor1

  • 1Harvard Medical School, Reproductive Endocrine Unit, National Center for Infertility Research, Massachusetts General Hospital, Boston 02114, USA. aetaylor@partners.org

Journal of Pediatric Endocrinology & Metabolism : JPEM
|December 16, 2000
PubMed
Summary

Polycystic ovary syndrome (PCOS) is linked to abnormal gonadotropin secretion, particularly elevated luteinizing hormone (LH). These hormonal changes appear early in PCOS development and are common in hyperandrogenic women.

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Area of Science:

  • Reproductive Endocrinology
  • Neuroendocrinology

Background:

  • Polycystic ovary syndrome (PCOS) is a common reproductive disorder.
  • PCOS is characterized by exaggerated gonadotropin secretion, including an elevated LH/FSH ratio and increased LH pulse frequency and amplitude.
  • These abnormalities suggest a potential hypothalamic defect, possibly present from puberty.

Purpose of the Study:

  • To investigate gonadotropin secretion patterns in women with PCOS compared to controls.
  • To explore the relationship between PCOS-related hormonal abnormalities and body mass index (BMI).
  • To determine if gonadotropin defects are an early or causal factor in PCOS development.

Main Methods:

  • Frequent blood sampling (q10 min for 8–12 hours) in 99 PCOS patients and 42 controls.
  • Analysis of mean LH levels, LH pulse amplitude and frequency, and LH/FSH ratios.

Related Experiment Videos

  • Correlation analysis with BMI and menstrual cycle phase.

    • Main Results:

    • Women with PCOS exhibited significantly elevated mean LH, LH pulse amplitude, LH pulse frequency, and LH/FSH ratios compared to controls.
    • These abnormalities were less pronounced during the luteal phase or early follicular phase.
    • A significant inverse relationship was observed between mean LH, LH/FSH ratio, LH pulse amplitude, and BMI.

    Conclusions:

    • Gonadotropin defects, especially elevated serum LH, are a predominant finding in hyperandrogenic women across different age groups.
    • These hormonal abnormalities appear early in the development of PCOS.
    • The precise cause of excess gonadotropin secretion in PCOS remains uncertain, with possibilities including a primary neuroendocrine abnormality or abnormal feedback mechanisms.