Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Stereotactic radiosurgery for cavernous malformations.

B E Pollock1, Y I Garces, S L Stafford

  • 1Department of Neurological Surgery, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA. bruce.pollock@mayo.edu

Journal of Neurosurgery
|December 16, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Low dose iodine-125 brachytherapy and transpupillary thermal therapy for small- to medium-sized choroidal melanoma.

Brachytherapy·2025
Same author

30-day morbidity and mortality after transoral robotic surgery for human papillomavirus (HPV) associated oropharyngeal squamous cell carcinoma: A retrospective analysis of two prospective adjuvant de-escalation trials (MC1273 & MC1675).

Oral oncology·2023
Same author

Scalable radiotherapy data curation infrastructure for deep-learning based autosegmentation of organs-at-risk: A case study in head and neck cancer.

Frontiers in oncology·2022
Same author

Phosphaturic Mesenchymal Tumor.

AJNR. American journal of neuroradiology·2022
Same author

Quantitative Modeling of External Ventricular Drain Output to Predict Shunt Dependency in Aneurysmal Subarachnoid Hemorrhage: Cohort Study.

Neurocritical care·2019
Same author

A cavernous sinus lesion clinically responsive to steroids.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2018
Same journal

Extent of resection as an independent predictor of survival for patients with glioblastoma as defined by the new WHO 2021 classification.

Journal of neurosurgery·2026
Same journal

Surgical treatment of schwannomas around the tarsal tunnel: a case series of 40 patients and systematic review of the literature.

Journal of neurosurgery·2026
Same journal

Direct targeting for focused ultrasound thalamotomy in the treatment of movement disorders.

Journal of neurosurgery·2026
Same journal

Development and internal validation of the Meningioma Functional Outcome Risk and Counseling Estimator 6 score, a point-based prognostic tool for predicting 6-week functional independence after intracranial meningioma resection.

Journal of neurosurgery·2026
Same journal

Connectional anatomy of the cerebellum: dentate nucleus and cerebellar peduncles from a surgical perspective.

Journal of neurosurgery·2026
Same journal

Press releases in neurosurgery: is scientific accuracy compromised in public reporting of neurosurgery research?

Journal of neurosurgery·2026
See all related articles

Stereotactic radiosurgery for cerebral cavernous malformations (CMs) may reduce bleeding risk after a delay, but carries a high complication rate. The risks of radiation-related complications are greater for CMs than for arteriovenous malformations (AVMs).

Area of Science:

  • Neurosurgery
  • Radiation Oncology
  • Neurology

Background:

  • Cerebral cavernous malformations (CMs) are vascular malformations that can cause neurological symptoms, including hemorrhage.
  • Stereotactic radiosurgery (SRS) is a treatment option for CMs, particularly in high-surgical-risk patients, but its efficacy and safety remain controversial.

Purpose of the Study:

  • To evaluate the efficacy and safety of SRS for treating cerebral cavernous malformations (CMs).
  • To compare the outcomes of SRS for CMs with those for arteriovenous malformations (AVMs).

Main Methods:

  • Retrospective review of 17 patients with high-surgical-risk CMs treated with SRS.
  • Median follow-up of 51 months; hemorrhage rates before and after SRS were compared.
  • Comparison of complication rates with 31 patients who underwent SRS for AVMs.

Related Experiment Videos

Main Results:

  • Annual hemorrhage rate decreased from 40.1% pre-SRS to 8.8% within 2 years and 2.9% thereafter.
  • 59% of patients developed new neurological deficits post-SRS, with a 41% permanent radiation-related morbidity rate.
  • SRS for CMs resulted in significantly higher rates of any complication (59% vs. 10%) and permanent complication (41% vs. 10%) compared to AVMs.

Conclusions:

  • SRS for CMs may offer some reduction in hemorrhage risk after a latency period, but definitive protection is not proven.
  • The risk of radiation-related complications following SRS for CMs is substantially higher than for AVMs.
  • The data suggest caution in using SRS for CMs due to the significant risk of permanent morbidity.