Prognosis of cancers associated with venous thromboembolism
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View abstract on PubMed
Summary
This summary is machine-generated.Cancer diagnosed concurrently with or shortly after venous thromboembolism indicates advanced disease and poor prognosis. This finding highlights the critical link between these conditions for cancer patients.
Area Of Science
- Oncology
- Hematology
- Epidemiology
Background
- Prognosis for cancer diagnosed during or after venous thromboembolism is poorly understood.
- Venous thromboembolism (VTE) is a common complication in cancer patients.
Purpose Of The Study
- To investigate the prognosis of cancer diagnosed concurrently with or within one year after an episode of venous thromboembolism.
- To compare the survival rates and cancer stage of patients with VTE and cancer to those with cancer alone.
Main Methods
- Utilized Danish national registries (Patient, Cancer, Mortality) to identify patients diagnosed with cancer at the time of or after VTE.
- Matched VTE-cancer patients with cancer-only control patients based on cancer type, age, sex, and diagnosis year.
- Analyzed survival rates, distant metastasis prevalence, and mortality ratios between the groups.
Main Results
- Cancer diagnosed concurrently with deep venous thromboembolism showed a higher prevalence of distant metastasis (44.0% vs. 35.1%) and a significantly lower one-year survival rate (12% vs. 36%).
- Patients diagnosed with cancer within one year after VTE also had an increased risk of distant metastasis (PR 1.23) and reduced one-year survival (38% vs. 47%).
- Overall mortality ratio for cancer with VTE was 2.20 compared to controls.
Conclusions
- Cancer diagnosed at the time of or within one year following venous thromboembolism is associated with advanced disease stage.
- These patients face a significantly poorer prognosis and increased mortality compared to cancer patients without VTE.
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