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Related Experiment Videos

Candida albicans cellular internalization: a new pathogenic factor?

L Drago1, B Mombelli, E De Vecchi

  • 1Laboratory of Clinical Microbiology, Department of Preclinical Science and L. Sacco Teaching Hospital, University of Milan, L.I.T.A. Vialba, Via G.B. Grassi 74, 20157 Milan, Italy. microbio@mailserver.unimi.it

International Journal of Antimicrobial Agents
|December 19, 2000
PubMed
Summary

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Candida albicans can enter epithelial cells, suggesting a mechanism for recurrent infections. This finding offers a new model for developing antifungal therapies against Candida albicans.

Area of Science:

  • Microbiology
  • Cell Biology
  • Pathogenesis

Background:

  • Recurrent oral and vaginal infections caused by Candida albicans are common.
  • The mechanisms by which Candida albicans invades host cells are not fully understood.

Purpose of the Study:

  • To investigate the possibility of Candida albicans internalization into epithelial cells.
  • To explore potential therapeutic strategies against Candida albicans infections.

Main Methods:

  • Incubation of buccal, vaginal, and HeLa cells with Candida albicans.
  • Elimination of non-internalized yeasts.
  • Examination of samples using Scanning Electron Microscopy.

Main Results:

  • Preliminary results indicate that Candida albicans can internalize into epithelial cells.

Related Experiment Videos

  • Scanning Electron Microscopy visualized the interaction between yeast and host cells.
  • Receptor-mediated endocytosis is suggested as a potential internalization mechanism.

    • Conclusions:

    • Candida albicans internalization into epithelial cells is possible.
    • This phenomenon may play a role in the pathogenesis of recurrent oral and vaginal candidiasis.
    • The observed internalization provides a model for testing drugs against Candida albicans infections.