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P2 purinergic receptors of human eosinophils: characterization and coupling to oxygen radical production
D Ferrari1, M Idzko, S Dichmann
1Department of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, Italy. dfr@dns.unife.it
FEBS Letters
|December 20, 2000
Abstract:
Extracellular nucleotides elicit multiple responses in eosinophils but no information on expression of purinergic receptors in these cells is available so far. In the present study we show that human eosinophils express the following P2Y and P2X subtypes: P2Y(1), P2Y(2), P2Y(4), P2Y(6), P2Y(11), and P2X(1), P2X(4), P2X(7), whose stimulation results in intracellular Ca(2+) increase and production of large amounts of reactive oxygen intermediates. These events are stimulated or inhibited, respectively, by P2 receptor agonists or antagonists.