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Basal 17beta-estradiol did not correlate with ovarian response and in vitro fertilization treatment outcome
P Phophong1, D M Ranieri, I Khadum
1Assisted Conception Unit, University College London Hospital, London, United Kingdom.
Objective:
To verify the correlation of basal 17beta-E(2) with ovarian response to stimulation and outcome of in vitro fertilization (IVF).
Design:
Retrospective observational study.
Setting:
The Assisted Conception Unit, University College London Hospitals.
Patient(S):
Three hundred five women undergoing IVF and IVF with intracytoplasmic sperm injection.
Intervention(S):
Basal follicle-stimulating hormone (FSH) and 17beta-E(2) were assessed. The cutoff level for day 2 E(2) established was 250 pmol/L. Each patient was noted for below (group A) or above (group B) the cutoff point according to her basal E(2) level.
Main Outcome Measure(S):
Basal E(2), age, duration of infertility, cycle day 2 FSH, number of ampules of gonadotropin used, number of days of stimulation, number of retrieved oocytes, fertilization rate, number of embryos transferred, number of cycles with embryo freezing, cancellation rate, clinical pregnancy rate, and implantation rate were compared between the two groups.
Result(S):
No differences were found between group A and group B in the number of oocytes retrieved (8.8 +/- 4.2 vs. 9.3 +/- 4.8), embryos transferred (2.5 +/- 0.8 vs. 2.7 +/- 0.7), cancellation (9.1% vs. 6.9%), pregnancy (24.8% vs. 30%), and implantation rate (12.3% vs. 15.6%). Correlation coefficient and coefficient of determination showed no significant correlation between basal E(2) and the number of oocytes retrieved, age, and basal FSH.
Conclusion(S):
In our study population, basal E(2) was not a sensitive predictor of ovarian response to stimulation and did not correlate with IVF outcome.