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Updated: Aug 1, 2026

Detection of Ligand-activated G Protein-coupled Receptor Internalization by Confocal Microscopy
10:24

Detection of Ligand-activated G Protein-coupled Receptor Internalization by Confocal Microscopy

Published on: April 9, 2017

Three distinct types of GnRH receptor characterized in the bullfrog

L Wang1, J Bogerd, H S Choi

  • 1Hormone Research Center and Department of Biology, Chonnam National University, Kwangju 500-757, Republic of Korea.

Proceedings of the National Academy of Sciences of the United States of America
|December 20, 2000
PubMed

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G-protein Coupled Receptors

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G Protein-coupled Receptors01:15

G Protein-coupled Receptors

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Activation and Inactivation of G Proteins

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Transducer Mechanism: G Protein–Coupled Receptors

G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
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Cholinergic Receptors: Muscarinic

The pharmacological actions of acetylcholine are elicited via its binding to two families of cholinergic receptors or cholinoceptors, namely, muscarinic and nicotinic receptors. Muscarinic receptors are G protein-coupled receptors and have five subtypes, M1–M5. All mAChR subtypes are activated by acetylcholine and blocked by the antagonist, atropine. 
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Cholinergic Receptors: Nicotinic

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