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Cardiovascular disease in chinese type 2 diabetic women is associated with a prolonged QTc interval

G T Ko1, J C Chan, J A Critchley

  • 1Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, N.T., Shatin, Hong Kong. gtc_ko@hotmail.com

International Journal of Cardiology
|December 21, 2000
PubMed

Insights

In Chinese type 2 diabetic women, a prolonged QT interval is linked to increased cardiovascular disease risk. Age, systolic blood pressure, and female gender independently correlate with this QT interval measurement.

Area of Science:

  • Cardiology
  • Diabetology
  • Clinical Research

Background:

  • Type 2 diabetes is a growing global health concern.
  • Cardiovascular disease (CVD) is a major complication of diabetes.
  • QT interval prolongation is a potential indicator of cardiac risk.

Purpose of the Study:

  • To investigate the relationship between QT interval and cardiovascular disease in Chinese type 2 diabetic patients.
  • To identify factors associated with QT interval prolongation in this population.

Main Methods:

  • Cross-sectional study of 192 Chinese type 2 diabetic patients (132 women, 60 men).
  • Electrocardiographic assessment of QTc interval.
  • Statistical analysis including multiple regression to identify independent predictors of QTc interval.

Main Results:

  • Women had significantly longer QTc intervals than men.
  • Prolonged QTc interval was associated with a 2.8-fold higher rate of cardiovascular disease in women.
  • Systolic blood pressure, age, and female gender were independently associated with QTc interval.

Conclusions:

  • A prolonged QTc interval is significantly associated with cardiovascular disease in Chinese type 2 diabetic women.
  • Age, systolic blood pressure, and female gender are independent predictors of QTc interval in this cohort.

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