Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Small, dense low-density lipoprotein subclass pattern B: issues for the clinician.

H R Superko1

  • 1Cholesterol, Genetics, and Heart Disease Institute, Berkeley HeartLab, Lawrence Berkeley National Laboratory, University of California, Berkeley, USA.

Current Atherosclerosis Reports
|December 21, 2000
PubMed
Summary

Coronary artery disease (CAD) is linked to lipoprotein metabolism disorders, especially Small, Dense Low-Density Lipoprotein Pattern B (Atherogenic Lipoprotein Profile). This condition accelerates CAD progression and is treatable with lifestyle changes and medication.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Role of Diet, Exercise, and Medication in Blood Lipid Management of Cardiac Patients.

The Physician and sportsmedicine·2016
Same author

Effects of a Mandatory Health Screening and Physical Maintenance Program for Law Enforcement Officers.

The Physician and sportsmedicine·2016
Same author

Providing patients with pharmacogenetic test results affects adherence to statin therapy: results of the Additional KIF6 Risk Offers Better Adherence to Statins (AKROBATS) trial.

The pharmacogenomics journal·2013
Same author

Prediction of native coronary artery disease progression following PTCA or CABG in the Emory Angioplasty Versus Surgery Trial.

Medical science monitor : international medical journal of experimental and clinical research·2003
Same author

Small LDL and hsCRP as new risk factors for coronary artery disease.

Journal of the Medical Association of Georgia·2002
Same author

Metabolic disorders contribute to subclinical coronary atherosclerosis in patients with coronary calcification.

The American journal of cardiology·2001

Area of Science:

  • Cardiovascular Medicine
  • Metabolic Disorders
  • Lipidology

Background:

  • Coronary artery disease (CAD) is significantly influenced by lipoprotein metabolism disorders.
  • These disorders arise from a complex interplay between genetic predisposition and environmental factors.

Purpose of the Study:

  • To highlight the role of Small, Dense Low-Density Lipoprotein Pattern B, also known as Atherogenic Lipoprotein Profile (ALP), in CAD.
  • To emphasize ALP as an independent risk factor and predictor of disease progression in CAD patients.

Main Methods:

  • Review of existing literature on lipoprotein metabolism and CAD.
  • Analysis of the clinical significance of Atherogenic Lipoprotein Profile in patient subgroups.

Main Results:

Related Experiment Videos

  • Atherogenic Lipoprotein Profile (ALP) is the most common lipoprotein disorder contributing to CAD.
  • ALP is an independent risk factor for CAD.
  • Patients with established CAD and ALP exhibit a twofold greater rate of arteriographic progression.

Conclusions:

  • Effective management of CAD involves addressing lipoprotein metabolism disorders like ALP.
  • Treatment strategies include lifestyle modifications and specific pharmacologic agents.
  • Cost-effective treatments, primarily lifestyle interventions, are often the most impactful for ALP.