Small, dense low-density lipoprotein subclass pattern B: issues for the clinician

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Published on: November 10, 2017

H R Superko1

  • 1Cholesterol, Genetics, and Heart Disease Institute, Berkeley HeartLab, Lawrence Berkeley National Laboratory, University of California, Berkeley, USA.

Current Atherosclerosis Reports
|December 21, 2000
PubMed

Insights

Coronary artery disease (CAD) is linked to lipoprotein metabolism disorders, especially Small, Dense Low-Density Lipoprotein Pattern B (Atherogenic Lipoprotein Profile). This condition accelerates CAD progression and is treatable with lifestyle changes and medication.

Area of Science:

  • Cardiovascular Medicine
  • Metabolic Disorders
  • Lipidology

Background:

  • Coronary artery disease (CAD) is significantly influenced by lipoprotein metabolism disorders.
  • These disorders arise from a complex interplay between genetic predisposition and environmental factors.

Purpose of the Study:

  • To highlight the role of Small, Dense Low-Density Lipoprotein Pattern B, also known as Atherogenic Lipoprotein Profile (ALP), in CAD.
  • To emphasize ALP as an independent risk factor and predictor of disease progression in CAD patients.

Main Methods:

  • Review of existing literature on lipoprotein metabolism and CAD.
  • Analysis of the clinical significance of Atherogenic Lipoprotein Profile in patient subgroups.

Main Results:

  • Atherogenic Lipoprotein Profile (ALP) is the most common lipoprotein disorder contributing to CAD.
  • ALP is an independent risk factor for CAD.
  • Patients with established CAD and ALP exhibit a twofold greater rate of arteriographic progression.

Conclusions:

  • Effective management of CAD involves addressing lipoprotein metabolism disorders like ALP.
  • Treatment strategies include lifestyle modifications and specific pharmacologic agents.
  • Cost-effective treatments, primarily lifestyle interventions, are often the most impactful for ALP.

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