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Genetic markers to predict polygenic disease.

¹Department of Human Metabolism and Genetics, St. Bartholomew's Hospital, London EC1A.7BE, UK.

Current Atherosclerosis Reports

|December 21, 2000

Summary

Genetic markers for common adult diseases are increasingly used for diagnosis and treatment. However, complex gene interactions complicate their application compared to single-gene disorders, necessitating careful consideration of potential misapplications.

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Area of Science:

Genetics
Medicine
Disease Prediction

Background:

Over 15 years, numerous genetic markers for multifactorial adult diseases have been identified.
Examples include Factor V Leiden for venous-thromboembolism, LPL mutations for hypertriglyceridemia, and APOE4 for Alzheimer's disease.

Purpose of the Study:

To discuss the emerging use of genetic markers in adult multifactorial diseases.
To highlight the complexities and potential misapplications of these markers.

Main Methods:

Review of identified genetic markers for common multifactorial diseases.
Comparison of genetic marker complexity in multifactorial versus monogenic disorders.

Main Results:

Genetic markers are being integrated into clinical practice for diagnosis, prognosis, and therapy targeting.
Gene-gene and gene-environment interactions significantly increase the complexity of using these markers.

Conclusions:

The application of genetic markers for multifactorial diseases is more intricate than for monogenic disorders.
Potential misapplications warrant careful consideration and further research.

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