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Related Experiment Videos

The low-density lipoprotein receptor family: genetics, function, and evolution.

W J Schneider1, J Nimpf, C Brandes

  • 1Department of Molecular Genetics, University and Biocenter Vienna, Dr. Bohr-Gasse 9/2, A-1030 Vienna, AUSTRIA.

Current Atherosclerosis Reports
|December 21, 2000
PubMed
Summary

The low-density lipoprotein receptor supergene family is expanding into new physiological roles. New members interact with diverse molecules and signaling pathways, broadening their functions beyond lipid metabolism.

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Area of Science:

  • Molecular biology
  • Genetics
  • Biochemistry

Background:

  • The low-density lipoprotein receptor (LDLR) supergene family plays a crucial role in lipoprotein metabolism.
  • Recent advancements in molecular biology reveal a rapid expansion of this gene family.
  • New LDLR family members are implicated in diverse physiological and developmental processes.

Purpose of the Study:

  • To review the expanding functional spectrum of the LDLR supergene family.
  • To explore the molecular mechanisms driving this functional diversification.
  • To discuss the evolutionary history of the LDLR gene family.

Main Methods:

  • Literature review of recent studies on LDLR family members.
  • Analysis of protein-ligand interactions involving LDLR extracellular domains.

Related Experiment Videos

  • Investigation of cytoplasmic tail interactions with signaling pathway components.

    • Main Results:

    • The LDLR supergene family has expanded significantly beyond its role in lipoprotein metabolism.
    • Functional diversification is driven by interactions with non-apolipoprotein ligands via extracellular domains.
    • Cytoplasmic tails of LDLR family members interact with adaptor proteins in signaling pathways.

    Conclusions:

    • The LDLR supergene family exhibits a broadened functional repertoire due to novel molecular interactions.
    • Understanding evolutionary events, both divergent and convergent, is key to delineating the family's history.
    • This expansion highlights the versatility of LDLRs in diverse biological contexts.