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Gene therapy in lung cancer

S G Swisher1, J A Roth

  • 1Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Box 109, Houston, TX 77030, USA.

Current Oncology Reports
|December 21, 2000
PubMed

Insights

Gene therapy offers new hope for non-small-cell lung cancer patients by transferring therapeutic genes. Early trials show replacing tumor suppressor genes like p53 is safe and feasible.

Area of Science:

  • Oncology
  • Molecular Biology
  • Gene Therapy

Background:

  • Non-small-cell lung cancer (NSCLC) has poor survival rates despite current treatments.
  • Novel therapeutic strategies are urgently needed for effective NSCLC treatment.

Purpose of the Study:

  • To explore gene therapy as a novel approach for non-small-cell lung cancer.
  • To evaluate the feasibility and safety of transferring therapeutic genes in NSCLC.

Main Methods:

  • Gene transfer technologies are utilized to deliver therapeutic genes.
  • Strategies include immune stimulation, suicide gene transfer, oncogene inactivation, tumor suppressor gene replacement, and pro-apoptotic gene transfer.
  • Clinical trials are initiated to assess these gene therapy approaches.

Main Results:

  • Transferring tumor suppressor genes, specifically wild-type p53, has been demonstrated as feasible.
  • The approach of transferring wild-type p53 exhibits low overall toxicity in preliminary studies.

Conclusions:

  • Gene therapy, particularly the transfer of tumor suppressor genes like p53, shows promise for non-small-cell lung cancer treatment.
  • Further clinical trials are underway to determine the therapeutic potential of gene therapy in NSCLC.

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