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Mucosa-associated lymphoid tissue lymphomas.

M Gospodarowicz1, R Tsang

  • 1Department of Radiation Oncology, Princess Margaret Hospital, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9. marykg@rmp.uhn.on.ca

Current Oncology Reports
|December 21, 2000
PubMed
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Mucosa-associated lymphoid tissue (MALT) lymphoma is a B-cell malignancy often presenting with localized disease. While local therapies can be curative, long-term follow-up is crucial for managing this condition.

Area of Science:

  • Oncology
  • Hematology
  • Immunology

Background:

  • Mucosa-associated lymphoid tissue (MALT) lymphoma is a distinct B-cell malignancy.
  • Characterized by lymphoepithelial lesions and specific immunophenotype (CD20+, CD5-, CD10-).
  • Associated molecular changes include trisomy 3 and translocations t(11;18), t(1;14).

Purpose of the Study:

  • To review the etiology, pathogenesis, clinical presentation, and management of MALT lymphoma.
  • To highlight the characteristic features and molecular alterations in MALT lymphoma.
  • To discuss treatment outcomes and the importance of long-term follow-up.

Main Methods:

  • Review of existing literature on MALT lymphoma.
  • Analysis of clinical and molecular characteristics.

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  • Synthesis of information on therapeutic approaches and patient outcomes.

    • Main Results:

    • MALT lymphomas commonly occur in extranodal sites like the stomach, orbit, salivary glands, and thyroid.
    • 60-70% of patients present with localized disease.
    • Lymphocyte homing is implicated in pathogenesis, particularly in gastrointestinal MALT.

    Conclusions:

    • Localized MALT lymphoma is often curable with local therapies (surgery, radiotherapy).
    • Chemotherapy can lead to prolonged survival but not necessarily cure.
    • Long-term follow-up is essential for understanding disease outcomes and management strategies.