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Related Experiment Videos

Intermittent androgen deprivation.

N A Dawson1

  • 1Division of Hematology/Oncology, University of Maryland Greenebaum Cancer Center, 22 South Greene Street, Baltimore, MD 21201-1595, USA. ndawson@umgcc.umaryland.edu

Current Oncology Reports
|December 21, 2000
PubMed
Summary

Intermittent androgen deprivation therapy offers potential benefits for prostate cancer patients, including improved quality of life. Ongoing trials will determine its role compared to continuous therapy.

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Area of Science:

  • Oncology
  • Urology

Background:

  • Intermittent androgen deprivation (IAD) is an evolving strategy for prostate cancer management.
  • Its efficacy and impact on quality of life require further investigation.

Purpose of the Study:

  • To review the current evidence for intermittent androgen deprivation in prostate cancer.
  • To discuss preclinical and clinical findings, and ongoing trials.

Main Methods:

  • Review of preclinical studies in animal models.
  • Analysis of Phase II clinical trials assessing quality of life and sexual function.
  • Discussion of ongoing Phase III trials comparing IAD with continuous androgen deprivation.

Main Results:

  • Preclinical models show delayed prostate-specific antigen (PSA) progression and androgen independence with IAD.
  • Phase II trials indicate improved sexual function and quality of life for patients on IAD.
  • Patients typically spend 37%-58% of treatment time off androgen deprivation and respond to retreatment.

Conclusions:

  • Intermittent androgen deprivation demonstrates potential benefits in preclinical and early clinical studies.
  • Ongoing Phase III trials are crucial to establish its comparative effectiveness and survival impact.
  • Currently, IAD is considered an experimental approach in prostate cancer management.

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