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Impulsive aggression in borderline personality disorder.

M Goodman1, A New

  • 1Psychiatry Service 116-A, Bronx Veterans Affairs Medical Center, 1130 West Kingsbridge Road, Bronx, NY 10468, USA.

Current Psychiatry Reports
|December 21, 2000
PubMed
Summary
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Impulsive aggression is a core feature of borderline personality disorder (BPD). Research suggests serotonin dysfunction plays a role, leading to targeted treatments like SSRIs for managing aggressive behaviors.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Genetics

Background:

  • Impulsive aggression is a significant factor in borderline personality disorder (BPD) morbidity and mortality.
  • A dimensional approach to BPD highlights impulsive aggression as a core symptom.
  • The serotonin hypothesis suggests an inverse relationship between central serotonin (5-HT) function and aggression/suicidality.

Purpose of the Study:

  • To explore the neurobiological underpinnings of impulsive aggression in BPD.
  • To review current research on the role of serotonin and associated neural pathways in aggression.
  • To discuss treatment implications based on neurobiological findings.

Main Methods:

  • Review of genetic, neurobiological, and diagnostic studies.
  • Examination of the serotonin hypothesis and its refinements.

Related Experiment Videos

  • Analysis of treatment studies for impulsive aggression in BPD.

    • Main Results:

    • Evidence supports a dimensional view of BPD with impulsive aggression as central.
    • Serotonin system dysfunction is implicated in the etiology of aggression and suicidality.
    • Research identifies specific brain regions, receptors, and neuromodulators involved.

    Conclusions:

    • Understanding the neurobiology of impulsive aggression informs BPD treatment.
    • Selective serotonin reuptake inhibitors (SSRIs) show promise in placebo-controlled trials.
    • Other treatments like atypical neuroleptics, mood stabilizers, and opioid antagonists are also being investigated.