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Related Experiment Videos

Personality in frontal lobe disorders.

T W Chow1

  • 1UCLA Frontotemporal Dementia Clinic, UCLA Alzheimer's Disease Research Center, University of California at Los Angeles, 710 Westwood Plaza, Los Angeles, CA 90095-1769, USA. twtwom@ucla.edu

Current Psychiatry Reports
|December 21, 2000
PubMed
Summary
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Personality changes in frontal lobe disorders are challenging to predict. Frontal-subcortical circuit syndromes explain many changes, but individual patient presentations can vary based on specific brain pathology.

Area of Science:

  • Neuroscience
  • Neurology
  • Behavioral Neurology

Background:

  • Personality changes are common in frontal lobe disorders but difficult to predict.
  • These changes stem from disruptions in prefrontal cortex or subcortical structures within frontal-subcortical circuits.
  • Existing classification systems for these changes may not fully capture individual patient variability.

Purpose of the Study:

  • To explore the complexities of personality changes associated with frontal lobe disorders.
  • To examine the relationship between neuroanatomic pathology and observed personality alterations.
  • To discuss the limitations of current assessment tools in predicting functional outcomes.

Main Methods:

  • Review of clinical observations and neurological classifications of personality changes.

Related Experiment Videos

  • Analysis of how focal lesions and diffuse neurodegenerative processes impact frontal-subcortical circuits.
  • Discussion of existing psychological instruments and their predictive capabilities.

    • Main Results:

    • Personality changes result from interrupted frontal-subcortical circuits, with varied presentations.
    • Three main frontal-subcortical circuit syndromes are recognized, but patients may exhibit mixed or selective features.
    • The orbitofrontal syndrome is associated with disinhibition and impulsivity, while apathy characterizes another end of the spectrum.

    Conclusions:

    • Personality changes in frontal lobe disorders are complex and influenced by specific neuroanatomic pathology.
    • Current classification systems offer a framework but do not encompass all patient presentations.
    • Predicting functional capacity and risk of violence remains challenging despite available assessment tools.