Clinical assessment and significance of inflammation in knee osteoarthritis

The recognition of the role of cytokines in osteoarthritis (OA) has suggested new approaches for therapy of the disease, and also increases the importance of clinical assessment of inflammation. Accurate identification of the presence and degree of inflammation might allow the clinician to predict which individuals would respond to therapy with anti-inflammatory drugs. Several laboratory and clinical markers have been evaluated which may also serve as predictors and indicators of response to therapy and overall outcome.